No differences between the apheresis and medication groups were found in mean segment diameter (−0.01☐.16 mm versus 0.03☐.16 mm, respectively) or in minimal obstruction diameter (−0.01☐.13 mm versus 0.01☐.11 mm, respectively), expressed as means per patient. Primary quantitative coronary angiographic end points were changes in average mean segment diameter and minimal obstruction diameter. The mean reduction in LDL cholesterol was 63% (to 3.0 mmol
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Methods and Results For 2 years, 42 men were treated with either biweekly LDL-apheresis plus medication or medication alone. To assess the effect of more aggressive lipid lowering with LDL-apheresis, we set up a randomized study in men with hypercholesterolemia and severe coronary atherosclerosis. LDL-apheresis has the potential to decrease LDL cholesterol to very low levels.
The player must lead the protagonist out of the dungeons and to the palace tower, defeating Jaffar and freeing the Princess in under 60 minutes. The game's nameless protagonist, whom the Princess loves, is thrown into the palace dungeons. Jaffar locks her in a tower and orders her, under threat of execution, to become his wife.
Jaffar's only obstacle to the throne is the Sultan's daughter (although the game never specifically mentions how). While the sultan is fighting a war in a foreign land, his vizier Jaffar, a wizard, seizes power. Prince of Persia influenced a sub-genre known as the cinematic platformer, which imitated the sprawling non-scrolling levels, fluid animation, and control style. This was achieved by interspersing intelligent puzzles and deadly traps all along the path the player-controlled Prince had to take to complete the game-all this packaged in fluid, lifelike motion. The game managed to surprise and captivate the player despite being at first glance, repetitive. After the original release on the Apple II, Prince of Persia was ported to a wide range of platforms. Prince of Persia is a fantasy platform game, originally developed by Jordan Mechner and released in 1989 for the Apple II, that represented a great leap forward in the quality of animation seen in video games.